A team from the University of Coimbra, Portugal, managed to shed some light into the function of an enzyme though to be an important target for therapeutics against the TB bacteria (Mycobacterium tuberculosis).
With over 30 passed since the latest breakthrough treatment against tuberculosis was reported, new insights are needed for pharmacological approaches that are effective against the bacteria and result in less side effects.
With the active site of the enzyme identified and characterized, the next step will be to design drugs that inhibit its normal functioning leading to a reduction in the bacteria’s proliferation.
A patent from these results has already been filed and a publication in a major scientific journal should be expected soon.
It might be preliminary, but to be confirmed, it can develop into a major step in the fight against tuberculosis.
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